Childhood adversity predicts earlier onset of major depression but not reduced hippocampal volume
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چکیده
منابع مشابه
Childhood adversity predicts earlier onset of major depression but not reduced hippocampal volume.
Childhood adversity may influence severity and age of onset of depression, potentially mediated by greater vulnerability to an existing biochemical or neural mechanism. Prior studies have suggested that reduced hippocampal volume is a result of childhood adversity. This study examined the relationship between childhood adversity, hippocampal volumes and clinical characteristics in women who wer...
متن کاملDepression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression.
This study takes advantage of continuing advances in the precision of magnetic resonance imaging (MRI) to quantify hippocampal volumes in a series of human subjects with a history of depression compared with controls. We sought to test the hypothesis that both age and duration of past depression would be inversely and independently correlated with hippocampal volume. A sample of 24 women rangin...
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OBJECTIVE Dysfunction of neuronal plasticity or remodelling seems to contribute to the pathopysiology of major depression and may cause the well-documented hippocampal changes in depression. We aimed to investigate whether reduced hippocampal volumes correlate with executive dysfunctioning or memory dysfunctioning or with depression severity. METHODS We recruited 34 inpatients with a previous...
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BACKGROUND Abnormalities in the prefrontal cortex have been implicated in the pathogenesis of major depressive disorder (MDD). To our knowledge, no prior study has examined prefrontal cortical anatomy in pediatric patients with MDD near the onset of illness before receiving treatment. METHODS Volumetric magnetic resonance imaging studies were conducted in 22 psychotropic-naive patients with M...
متن کاملHippocampal volume in early onset depression
BACKGROUND Abnormalities in limbic structures have been implicated in major depressive disorder (MDD). Although MDD is as common in adolescence as in adulthood, few studies have examined youth near illness onset in order to determine the possible influence of atypical development on the pathophysiology of this disorder. METHODS Hippocampal volumes were measured in 17 MDD subjects (age = 16.67...
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ژورنال
عنوان ژورنال: Psychiatry Research: Neuroimaging
سال: 2008
ISSN: 0925-4927
DOI: 10.1016/j.pscychresns.2007.04.004